Mapping genotype to phenotype

Cystic fibrosis from genotype to phenotype: review article

Cystic fibrosis (CF) is the most common autosomal recessive genetic disease, which is caused by defection in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. CFTR gene codes chloride channels to modulate the homeostasis of epithelial environments. Defective CFTR affects various organs such as the lungs, pancreas, intestine, liver and skin; however, lung impairment is the mai...

Genotype-phenotype mapping: genes as computer programs.

The effects of genes on phenotype are mediated by processes that are typically unknown but whose determination is desirable. The conversion from gene to phenotype is not a simple function of individual genes, but involves the complex interactions of many genes; it is what is known as a nonlinear mapping problem. A computational method called genetic programming allows the representation of cand...

Domain-Independent Genotype to Phenotype Mapping through XML Rules

This paper discusses an innovative approach to mapping Genotypes to Phenotypes through XML rules. Specifically, it concentrates on the mapping process using two very different domains – Regular Expressions (REs) and Software Program Statements. The paper shows that our Genotype-Phenotype system can be applied to any domain that requires the use of REs and it can be adapted to work for any other...

Coevolution of genotype-phenotype mapping to solve highly epistatic problems

Genotype-phenotype mapping plays an important role in the evolutionary process. In this paper, we argue that an adaptive mapping could help to solve a special class of highly epistatic problems known as rotated problems. Our conjecture is that co–evolving the mapping represented by a population of matrices in parallel with the genotypes will overcome the problem of epistasis. We use the fast ev...

Phenomics: Genotype to Phenotype